OpenBiome Logo Horizontal TealType University of Cape Towncurrent research text box

Majdi OsmanPrincipal Investigator: Dr. Majdi Osman, Dr. Shrish Budree

Disease: Severe Acute Malnutrition

Research Description: Globally, approximately 19 million children under the age of 5 are affected by severe acute malnutrition (SAM) annually. Current approaches to treatment have only modest effects with approximately 30% of children failing to respond to standard nutritional therapy. There is emerging evidence that disturbances in the gut microbiota, the trillions of bacteria residing in the gastrointestinal tract, are causally related to poor recovery in malnutrition. Fecal microbiota transplantation (FMT) is widely used for the treatment of C. difficile infections and is recommended in clinical guidelines for adults and children. The THRIVE study is investigating the safety and clinical response to FMT in children with SAM unresponsive to standard therapy. THRIVE is a single-center, randomized controlled, pilot study in 20 South African children in the recovery phase of SAM. The THRIVE study is the first to explore broad-spectrum microbiome interventions for the treatment of SAM and could catalyze novel therapeutic avenues to address SAM.

CWR Funding Role: Participating funder

CWR Funding Partner: Multiple anonymous funders

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