MCWgreen current research text box

Alvarez headshot May 2018Principle Investigator: Dr. Rita V. Alvarez

Disease: Pediatric delirium

Research Description: Altered cognition and consciousness defines delirium. Delirium is a common syndrome in critically ill children, with up to 66% of children in the pediatric intensive care unit (ICU) developing delirium. Delirium leads to increased length of mechanical ventilation, length of ICU stay, mortality and healthcare costs. Currently, there is no approved drug therapy for pediatric delirium. The proposed research will test quetiapine, an FDA approved atypical antipsychotic, in children diagnosed with delirium in the pediatric ICU. The research team will conduct a prospective double-blind, randomized controlled clinical trial to determine if quetiapine is safe and effective in decreasing the duration of pediatric delirium in critically ill children. If successful, quetiapine could be used off label for the treatment of pediatric delirium.

CWR Funding Role: Participating funder

CWR Funding Partner: Goldman Philanthropic Partnerships

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