Recently Completed Research

Recently Completed Repurposing Research

 

Recently completed repurposing researcher in the lab Recently completed repurposing research trias have been finished within the last five years. Funding the latest research supports clinicians and researchers across the country who are pursuing and discovering new indications for complex diseases.

We support repurposing research for any and all disease areas including cardio, neuro, oncology, ophthalmic, vascular and rare diseases in pediatrics and adults. Research projects are dedicated to repurposing approved drugs, devices, diagnostics, nutraceuticals and combination products. Recently completed repurposing research projects often include proof-of-concept clinical trials or other preclinical studies to evaluate the efficacy and appropriate uses for repurposing. Successful researchers often leverage positive data into follow-on funding.

Our impact philanthropy approach prioritizes the patient. Our funding helps complete repurposing research for philanthropic projects which have critical value and impact on patients, but little or no commercial value. We also fund commercial repurposing projects. This may result in industry bringing these projects to regulatory approval and then to market. Patients benefit from having additional treatment options.

We follow completed repurposing research trials for up to 5 years measuring our funding’s patient and scientific impact in many ways, including a) the leverage of positive data into follow-on funding; b) papers published or presented; c) larger clinical trials conducted; and d) positive patient outcomes.

Click HERE to see a map of our recently completed trials!

 

Completed in the last 5 years

DISEASE AREAINSTITUTIONLEAD RESEARCHERPROJECT NAMETYPEOTHERSTATUS
Diabetic OphthalmologyNorthwestern UniversityDr. BastiTreating Cataracts in Diabetic Patients Using a Surgical DeviceDeviceAdultCompleted 2023
DiabetesMassachusetts General HospitalDr. FaustmanRepurposing a Vaccine for Type I DiabetesVaccineAdultCompleted 2024
Ear Nose ThroatCurtin UniversityDr. BrownTesting a generic diuretic to improve drug delivery to the inner ear in Meniere’s diseaseDrugPre-ClinicalCompleted 2021
Ear Nose ThroatStanford MedicineDrs. Grimes, Santa MariaModulating inner ear fluid regulation to treat Meniere’s diseaseDrugPre-ClinicalCompleted 2022
Ear Nose ThroatThe Feinstein Institutes for Medical ResearchDr. PathakInvestigating the effects of repurposed diuretic, steroid and immunosuppressive drugs in Meniere’s diseaseDrugPre-ClinicalCompleted 2023
Ear Nose ThroatMedical University of South CarolinaDr. RizkAssessing the efficacy of an antidepressant for improving vertigo attacks in Meniere’s diseaseDrugAdultCompleted 2023
Ear Nose ThroatUniversity Hospital of MunichDr. StruppCombining a vertigo drug with a Parkinson’s disease drug to treat the inner ear disorder, Meniere’s diseaseDrugAdultCompleted 2023
Ear Nose Throat/Infectious DiseaseUniversity College Hospital IbadanDr. Jatto
- Researcher Spotlight available here
Repurposing a Widely Available Antiseptic in Pediatric Chronic Ear Infections in Nigeria DrugPediatricCompleted 2023
GIOpenBiome, University of Cape TownDrs. Osman, BudreeThe THRIVE Study: Repurposing Fecal Microbiota Transplantation for the Treatment of Pediatric Malnutrition in South Africa *OtherPediatricCompleted 2020
Infectious DiseaseNorthwestern UniversityDr. RadoRepurposing an Antidepressant to Prevent Hospitalization in COVID-19DrugAdultCompleted 2021
Infectious DiseaseObafemi Awolowo University & Teaching Hospitals ComplexProf. Adewole
- Researcher Spotlight available here
Treating Tuberculosis with the Lipid Lowering Drug Atorvastatin in NigeriaDrugAdultCompleted 2022
Infectious Disease/GIBoston Children's HospitalDr. KahnFecal Microbiota Transplantation Patient Registry for Pediatric C-diffOtherPediatricCompleted 2021
Liver Disease/RareChildren's National Health System, University of Illinois at ChicagoDr. Nadler, Dr. HoltermanUsing a Cancer Drug to Treat a Rare Pediatric Liver DiseaseDrugPediatricCompleted 2019
Metabolic Disorder/RareChildren's Hospital of Philadelphia, The Hospital for Sick ChildrenDrs. Levine, Sochett
- Researcher Spotlight available here
Repurposing an Antibiotic to Treat a Defect in Vitamin D MetabolismDrugPediatricCompleted 2020
NeuroUniversity of Pennsylvania MedicineDr. OathesUsing Imaging Techniques to Guide Targeted Brain Stimulation in the Treatment of Depression and Post-Traumatic Stress DisorderDeviceAdultCompleted 2021
Neuro/RareMcGovern Medical School at The University of Texas Health Science Center at HoustonDr. Furr-Stimming - Researcher Spotlight available hereTreating Irritability in Huntington’s Disease with a Repurposed Neurological DrugDrugAdultCompleted 2023
NeuroThe Pennsylvania State University and the Milton S. Hershey Medical CenterDr. Elfar
- Researcher Spotlight available here
Repurposing a Multiple Sclerosis Drug in Severe Limb Trauma*DrugAdultCompleted 2022
NeuroCincinnati Children's Hospital Medical CenterDr. WinkRepurposing a Generic Drug in Autism Spectrum DisorderDrugPediatricCompleted 2019
NeuroUniversity of TorontoDr. Lanctôt - Researcher Spotlight available hereA new opportunity to treat behavioral problems in Alzheimer’s patientsDrugAdultCompleted 2019
NeuroUniversity of New MexicoDr. Lewine - Researcher Spotlight available hereRepurposing N-Acetylcysteine to Reduce Oxidative Stress, an Important Factor in Traumatic Brain InjuryDrugAdultCompleted 2023
NeuroRush University Medical CenterDr. Voigt-ZuwalaEnhancing Posttraumatic Stress Disorder Treatment for Veterans via Prebiotic SupplementationNutraceuticalAdultCompleted 2024
Neuro/RareGeorgetown UniversityDr. AndersonUsing a Cancer Drug in Huntington's Disease DrugAdultCompleted 2022
OncologyUniversity of ChicagoDrs. Chmura, BestvinaInnovations in Combination Therapies for Non-Small Cell Lung Cancer DrugAdultCompleted 2020
Oncology/RareJohns Hopkins MedicineDr. RigginsA Phase I Trial for Recurrent Pediatric Brain Cancers Using a Repurposed Generic DrugDrugPediatricCompleted 2019
Oncology/RareUniversity of MichiganDr. SwiecickiRepurposing Old Drugs as New Therapies for Metastatic Thyroid Cancer*DrugAdultCompleted 2024
Oncology/Rare/NeuroMassachusetts General Hospital/Harvard Medical School, VUmc Cancer Center AmsterdamDr. TannousA Novel Combination of Generic Chemotherapy Drugs to Treat Brain CancerDrugAdultCompleted 2023
Oncology/RareUlm UniversityDr. HalatschCombining Nine Repurposed Drugs with a Current Chemotherapy Treatment in Adult Brain Cancer Drug AdultCompleted 2020
OphthalmicUniversity of Pennsylvania MedicineDr. KimRepurposing a Nutraceutical to Treat a Type of Age-Related Macular DegenerationNutraceuticalAdultCompleted 2019
Ophthalmic/RareUniversity of California, DavisDr. Park - Researcher Spotlight available hereRepurposing Bone Marrow Stem Cell Therapy for Vision Loss Caused by Retinitis Pigmentosa OtherAdultCompleted 2023
OtherKEMRI-Wellcome Trust Research ProgrammeDr. Hamaluba
- Researcher Spotlight available here
Testing the Safety of a Metal Poisoning Drug to Treat Snakebite in KenyaDrugAdultCompleted 2023
VascularUniversity of Illinois at ChicagoDrs. Havelka, Eton Saving Limbs from Chronic Ischemia: Helping Nature Do Its Magic*Drug/Device combo  AdultCompleted 2019

*CureAccelerator Live! winner