Principal Investigator: Dr. Luis Porrata
Disease: Non-Hodgkin Lymphoma
Research Description: Dr. Porrata’s clinical trial sought to improve the existing autologous stem cell transplant (ASCT) protocol used to treat non-Hodgkin's lymphoma patients. The existing method involved removing healthy blood cells from a patient, treating the patient with chemotherapy and then re-injecting the patient with their removed cells to regenerate a healthy blood system. By simply increasing both the total amount of cells and the relative amount of a specific cell type (natural killer cells) that are harvested and re-injected, the success rate of the procedure is increased. For almost no cost or additional risk, the rate of durable remissions seen in patients can increase from 50% to 70%. These protocol improvements can save lives and reduce healthcare costs for patients who suffer from a variety of blood cancers. Almost 600,000 ASCTs are performed around the world each year. This success could save up to 180,000 lives per year!
CWR funding role: Participating funder
Publication: Biology of Blood and Marrow Transplantation
→ Data are supporting a change in clinical practice
→ Data are supporting trials in other diseases using the same repurposing treatment