Research in Progress
Principal Investigator: Dr. Chani Traube
Disease: Pediatric delirium
Research Description: Delirium is disturbed consciousness, cognition and/or acute change in mental status and inattention. Delirium is recognized as a significant complication of critical illness, associated with increased mortality in adults. A growing body of pediatric literature suggests that delirium is a serious and under-recognized problem in critically ill children, yet little research has focused on treatment. Quetiapine, an FDA approved atypical antipsychotic, may be repurposed as an effective off-label treatment option for pediatric delirium. The proposed clinical research trial will test the drug in children diagnosed with delirium in the pediatric intensive care unit.
CWR funding role: Primary funder
Start date: October 1, 2015
Most recent report: Patient recruitment and data collection for this clinical trial are currently underway.
Anticipated next steps:
→ Data published in a scientific journal and/or presented at a scientific conference
→ Data are supporting off-label clinical use