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Kahn HeadshotPrincipal Investigator: Dr. Stacy Kahn

Disease: Clostridium difficile infection

Research Description: Fecal microbiota transplantation (FMT) is the repurposing of human stool to deliver healthy bacteria to the gastrointestinal tract of individuals with disease, most notably Clostridium difficile infection (CDI). CDI is an increasing health care burden and is the leading cause of hospital-associated gastrointestinal illness. FMT has become a cost effective and life-saving treatment for patients with recurrent and refractory Clostridium difficile infection who have not responded to conventional antibiotic treatment. Dr. Kahn will create a pediatric patient registry to study FMT in children. This patient registry will be used to study the natural history of CDI and the safety and efficacy of treatment with repurposed stool through FMT. Dr. Kahn will also pursue a proof concept clinical trial testing swallowed human microbiota capsules to treat CDI infections in children.

CWR funding role: Primary funder

Start date: Starting in 2016

Most recent report: Creation of the registry will begin in 2016.

Anticipated next steps:

→ Data published in a scientific journal and/or presented at a scientific conference 

→ Data are supporting off-label clinical use in the pediatric population

→ Data leveraged into larger philanthropic or government funding for this treatment

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