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Havelka photo copyPrincipal Investigators: Dr. George Havelka, Dr. Darwin Eton

Disease: Chronic limb-threatening ischemia

Research Description: Patients with Chronic Limb‐threatening Ischemia (CLI) suffer from impeded blood flow to their limbs. They present with foot pain, ulceration and/or gangrene. They require risky and costly revascularization operations to avoid amputation, although these surgeries are ineffective in many cases and amputations are sometimes required. Drs. Havelka and Eton have found that combining a compression device with a drug originally approved for use in cancer patients restored vascularization, significantly improves patient outcomes, eliminates the need for surgery and reduces amputation rates. This clinical study of CLI patients will describe the molecular effects of the repurposed treatment.

CWR funding role: Primary funder

Start date: Starting in 2016

Most recent report: Patient enrollment will begin in mid 2016.

Anticipated next steps:

→ Data published in a scientific journal and/or presented at a scientific conference 

→ Data leveraged into larger philanthropic or government funding for this treatment

→ Data are supporting off-label clinical use

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