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Cox headshotPrincipal Investigator: Dr. Zachary Cox

Disease: Heart failure

Research Description: Approximately 90% of heart failure admissions result from too much fluid in the blood. Loop diuretics are often used to treat this condition. However, some patients develop a resistance to loop diuretics, resulting in a recurrence of symptoms. Yet despite this frequent resistance, current international guidelines provide no clear guidance on the best method to restore diuretic efficacy. While the combination of loop diuretics with oral thiazides is the common practice, the current data on this treatment is limited. Off-label use of other diuretics, such as intravenous chlorothiazide or tolvaptan, in combination with loop diuretics might lead to better outcomes with less adverse events. This proof of concept clinical trial will compare the efficacy and safety of new diuretic combination therapies to overcome loop diuretic resistance in patients with heart failure.

CWR funding role: Participating funder

Start date: Starting in 2016

Most recent report: Patient enrollment will begin in 2016.

Anticipated next steps:

→ Data published in a scientific journal and/or presented at a scientific conference 

→ Data are supporting off-label clinical use

→ Data leveraged into larger philanthropic or government funding for this treatment

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