Rush University Medical Center

Borgia headshotPrincipal Investigator:  Dr. Jeffrey Borgia

Disease: Lung cancer

Research Description: Early detection of lung cancer can save lives. Low‐dose computer tomography (CT) screening in high‐risk lung cancer patients has been shown to reduce mortality. However, only a small percentage of the suspicious lesions identified on CT scans are malignant, leading to unnecessary biopsies or surgeries in many patients. Dr. Borgia and his team are repurposing a blood diagnostic test Dr. Borgia developed with prior Cures Within Reach funding to help clinicians rule out non‐malignant lung cancer cases in other clinical circumstances. This research project will repurpose this diagnostic test to determine if it could help sort out malignant from non‐malignant lesions, thereby improving physician decision making, patient care and outcomes and reducing healthcare costs following a CT screening scan.

CWR funding role: Primary funder

Start date: July 1, 2015 

Most recent report: A significant number of patients are enrolling in this screening study and blood samples are being collected. A maximum of 200-300 patients are expected to enroll per month. The hope is to screen up to 10,000 patients having CT scans for lung cancer, in order to produce robust results.

Anticipated next steps:

→ Data published in a scientific journal and/or presented at a scientific conference 

→ Data leads to a change in clinical practice to improve patient outcomes

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